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Adopren (Ibuprofen)

Active Ingredient: Ibuprofen
Dosage: 800 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 50 tablets per pack

Adopren (also known as ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID) that is used to treat mild to moderate pain, fever, inflammation, menstrual cramps, backache, and types of arthritis.

You can buy Adopren here.

Indications

Symptomatic treatment:

  • headache tension and migraine;
  • joint, muscle pain;
  • back pain, lower back, radiculitis;
  • pain when the ligaments are damaged;
  • toothache
  • painful menstruation;
  • feverish conditions with colds, flu;
  • rheumatoid arthritis, osteoarthrosis.

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, it does not affect the progression of the disease.

Dosage and administration

Use and dosage should always be prescribed by a doctor. The tablets can be taken with or without meals, always with a glass of water. It is recommended to take tablets with a full stomach to avoid stomach pain, especially when you are taking tablets for several days. The treatment usually lasts until the pain ceases, although it is not recommended to take it for prolonged periods since it can cause kidney, liver and gastrointestinal damage.

The recommended dose for adults:

  • 1 tablet for inflammation, pain in general, for a decrease in fever and flu symptoms – 4-6 times per day;
  • 1 tablet for painful menstruation – 3-4 times per day.

Medication in children: The use of Adopren in children under 12 years of age is not recommended. However, if needed and there is no other medication available, you can use half a tablet of 400 mg every 8 hours.

Contraindications

Do not take Adopren tablets if you have any of the following diseases/conditions:

  • hemorrhagic diathesis;
  • hypersensitivity to the drug;
  • severe renal failure;
  • active inflammatory bowel disease;
  • liver failure;
  • heart failure;
  • gastric ulcer, duodenal ulcer. A history of bleeding or relapse;
  • the last trimester of pregnancy;
  • perforation or bleeding from NSAIDs in the gastrointestinal tract;
  • clotting problems;
  • a history of hypersensitivity after other NSAIDs.

Side effects

  • Disorders of the lymphatic system and blood: hematopoiesis, including leukopenia (a decrease in the number of white blood cells), anemia, thrombocytopenia (a decrease in the number of platelets), pancytopenia (a decrease in the number of all blood cells), agranulocytosis (a decrease in the number of granulocytes), a decrease in hemoglobin level. The first signs of these disorders are sore throat, fever, superficial mouth ulcers, exhaustion, bleeding, bruising, and flu-like symptoms;
  • Immune system disorders: allergies (urticaria, itching, swelling of the face, larynx, tongue, impaired airway, palpitations, drop in blood pressure), other hypersensitivity reactions (asthma, exacerbation of asthma, bronchospasm, various forms of skin reactions, purpura, exfoliative or bullous dermatoses, including Stevens-Johnson syndrome, Lyell, erythema multiforme);
  • Disorders of the nervous system: aseptic meningitis (inflammation of the meninges), manifested by rigidity (numbness) of the occipital muscles, expressed by headache, vomiting, fever, disorientation;
  • Disorders of the heart and blood vessels: edema, heart failure, thrombotic complications (including stroke, myocardial infarction), increased pressure;
  • Respiratory tract disorders: bronchospasm (narrowing of the bronchi), shortness of breath;
  • Digestive disorders: changes in stool, abdominal pain, flatulence (bloating), constipation, gastric ulcer, duodenal ulcer, perforation, bleeding, melena (tarry stool), bloody vomiting, gastritis, ulcerative stomatitis, exacerbation of existing colitis, Crohn’s disease, impaired liver function;
  • Changes in the skin, subcutaneous tissue: erythema multiforme (redness), various types of skin rashes, toxic epidermal necrolysis (flaking of the upper layers of the skin), bullous reactions (blisters on the skin), including Stevens-Johnson syndrome;
  • Urinary disorders: acute renal impairment.

Overdose

Do not exceed the indicated dose of Adopren. If you exceed the dose, consult a doctor or the nearest medical facility immediately. Take the packaging of the drug with you.

Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, lowering blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.

Treatment: gastric lavage (only within an hour after ingestion), activated charcoal, alkaline drink, forced diuresis, symptomatic therapy (correction of the acid-base state, blood pressure).

Interaction

  • Increased risk of gastrointestinal ulcer and hemorrhage: NSAIDs, oral anticoagulants of the dicumarinic type, platelet antiaggregants of the AAS type, oral corticosteroids and SSRIs;
  • Reduced efficacy: furosemide, thiazide diuretics;
  • Reduced hypotensive effect: β-blockers, ACEI, angiotensin II antagonists;
  • Risk of hyperkalemia: potassium-sparing diuretics;
  • Reduced effect: mifepristone;
  • Increased plasma levels: digoxin, phenytoin and lithium;
  • Increased toxicity: methotrexate, hydantoins, sulfa drugs, baclofen;
  • Power gastrointestinal lesions: salicylates, phenylbutazone, indomethacin and other NSAIDs;
  • Increased effect: oral hypoglycemic agents and insulin;
  • Additive effect on platelet inhibition: ticlopidine;
  • Increased risk of hematotoxicity: zidovudine;
  • Power bleeding time: anticoagulants;
  • Increased risk of nephrotoxicity: tacrolimus, cyclosporine;
  • Increased risk of bleeding and gastrointestinal ulcer: corticosteroids, bisphosphonates or oxipentifiline, selective inhibitors of cyclooxygenase-2;
  • Risk of bleeding: ginkgo biloba, thrombolytics;
  • Increased plasma concentrations: probenecid and sulfinpyrazone;
  • Reduced effect: ion exchange resins (cholestyramine);
  • Potential toxicity: tacrine;
  • Enhanced nephrotoxic effect: aminoglycosides.