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Amoxibron (Amoxicillin, Bromhexine)

Active Ingredient: Amoxicillin, Bromhexine
Dosage: 500 mg/8 mg
Route of Administration: Oral
Dosage Form: Capsules
Quantity per package: 12 capsules

Amoxibron is an oral drug with bactericidal action. It is used to treat respiratory tract infections caused by gram + and gram-sensitive to amoxicillin that require the combined action of mucolytic agents: acute and chronic bacterial bronchitis, acute bacterial exacerbation of chronic bronchitis, acute post-influenza bacterial tracheobronchitis and during influenza, measles, exanthematous, bronchiectasis, whooping cough, pneumonia and bronchopneumonia.

Amoxibron is currently out of stock but you can find a similar medication on this page.

Indications

The drug is indicated for the treatment of respiratory tract infections caused by gram-positive and gram-negative microorganisms sensitive to amoxicillin, and when the abundant bronchial secretion justifies the desirability of the simultaneous use of a mucolytic agent.

Common indications include:

  • Acute and chronic bacterial bronchitis;
  • Acute bacterial exacerbations of chronic bronchitis;
  • Post-influenza acute bacterial tracheobronchitis;
  • Bronchiectasis;
  • Pneumonia and bronchopneumonia.

Dosage and administration

Adults: one 500 mg / 8 mg capsule every eight hours. Renal impairment: in these patients, amoxicillin and bromhexine must be dosed separately.

Contraindications

Patients with a history of hypersensitivity to beta-lactam antibiotics (eg, penicillins, cephalosporins).

Side effects

  • Hypersensitivity: pruritus, rashes, hives that sometimes disappear without having to stop treatment. Very rarely, patients have reported anaphylactic reactions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous and exfoliative dermatitis and generalized acute exanthematous pustulosis (AGEP). Severe allergic reactions, including angioneurotic edema, anaphylaxis, serum sickness and hypersensitivity vasculitis, have rarely been reported. In rare cases, interstitial nephritis may occur;
  • Renal and urinary tract disorders: in very rare cases, patients have reported crystalluria;
  • Infections and infestations: in very rare cases, mucocutaneous candidiasis has developed;
  • Gastrointestinal: Amoxicillin is well-tolerated. Hypersensitive patients may experience indigestion, stomach pain and flatulence. Common side effects are diarrhea and nausea. An uncommon effect is vomiting. Very rarely, the drug caused antibiotic-associated colitis (including pseudomembranous and hemorrhagic colitis), black hairy tongue;
  • Hematologic: during treatment with penicillins, transient leukopenia (including severe neutropenia or agranulocytosis), thrombocytopenia and hemolytic anemia have been noted. Prolonged bleeding time and prothrombin time have also been reported;
  • Hepatic: Some patients may experience a moderate increase in TGO or TGP concentrations. Hepatitis and cholestatic jaundice have rarely been reported;
  • CNS effects: seizures may occur in patients with impaired renal function or in those receiving high doses;
  • Miscellaneous: On very rare occasions, superficial alterations in the coloring of teeth in children have been reported. Good oral hygiene can help prevent changes in the color of the teeth since they can usually be removed by brushing.

See also  Azitrocin (Azithromycin)

Overdose

The treatment is symptomatic. In case of gastrointestinal symptoms, fluid monitoring and electrolyte balance are recommended. Amoxicillin can be removed from the circulation by hemodialysis. In some cases, amoxicillin crystalluria has been observed that leads to renal failure.

Interaction

Concomitant administration of allopurinol and amoxicillin may increase the risk of allergic skin reactions. Probenecid decreases renal tubular secretion of amoxicillin. Its concomitant use may result in an increase and prolongation of amoxicillin blood levels. Like other antibiotics, Amoxibron can affect the intestinal flora, decreasing estrogen reabsorption and reducing the effectiveness of combined oral contraceptives.