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Andantol (Isothipendyl)

Active Ingredient: Isothipendyl
Dosage: 25 g
Route of Administration: Local
Dosage Form: Jelly
Quantity per package: 1 unit
Availability: Out of stock

Why is Andantol not used in the USA

Despite its success abroad, Andantol is not available in the USA, primarily because it has not undergone the rigorous approval process required by the FDA. The U.S. market offers several established alternatives for anti-itch and skin care treatments, which likely diminishes the incentive for introducing new products like Andantol. Additionally, the costs and extensive resources needed for clinical trials and regulatory approval may deter manufacturers from pursuing FDA clearance for this particular medication.

Alternative Skin Care Drugs Sold in the USA

These alternatives offer similar symptomatic relief but vary in their active ingredients and indications:

What is Andantol?

Andantol is a potent antihistamine that is used for the topical treatment of itching and other skin conditions. The medicine contains isothipendyl hydrochloride as an active ingredient. It can also treat other allergic signs and relieve the symptoms of insect bites and sunburn.


Andantol is indicated in insect bites, sunburn, 1st and 2nd-degree burns, non-suppurative allergic dermatitis and itching.

Countries Where Andantol Is Used

Andantol is widely used in various Latin American countries due to its availability, effectiveness, and affordability in treating itching and related skin conditions. Its ease of application as a topical gel or cream and ability to offer quick relief makes it popular.

Dosage and administration

Depending on the case, a very thin layer should be administered on the skin every 8 hours.

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  • Hypersensitivity to the components of the formula;
  • Pregnancy;
  • Breastfeeding;
  • Diabetes.

Side effects

The sedative action is a side effect that occurs infrequently less than 1%. Other adverse reactions are dizziness, tinnitus, lassitude, fatigue, euphoria, loss of appetite and nausea (rarely).


An overdose of isothipendyl can cause CNS depression or stimulation. If vomiting has not occurred spontaneously it should be induced. Stimulants should not be used. Vasopressors can be used to treat hypotension.


Andantol, containing Isothipendyl, can interact with certain medications and substances, potentially affecting its efficacy or leading to adverse effects:

  1. Antihistamines: Andantol should not be used with other antihistamines as it may increase the risk of side effects like drowsiness and dry mouth.
  2. Alcohol: Consumption of alcohol while using Andantol can intensify its sedative effects, leading to increased drowsiness or impaired concentration.
  3. Sedatives and CNS Depressants: Combining Andantol with sedatives, tranquilizers, or other central nervous system depressants can amplify their sedative effects.
  4. MAO Inhibitors: If taken concurrently with monoamine oxidase inhibitors, which are used for treating depression, it may increase the risk of anticholinergic effects such as dry mouth, urinary retention, or constipation.

To prevent potential interactions, patients should consult a healthcare professional before combining Andantol with any other medication or substance.