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Dactil Ob (Piperidolate, Ascorbic Acid, Hesperidin)

Active Ingredient: Piperidolate, Ascorbic Acid, Hesperidin
Dosage: 100 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 30
Availability: Out of stock

Dactil Ob is prescribed for miscarriage and preterm birth. It is also intended for chemopreventive effects, scurvy, vitamin deficiency, inflammation, and other conditions. These tablets may also be applied for purposes not listed in this medication guide. This drug produces ascorbic acid. It is reversibly oxidizing dehydroascorbic acid in the body. It is suppressing the expression of inflammatory enzymes and proinflammatory cytokines. Dactil Ob is currently unavailable. Follow the link and buy another treatment option for health improvement.

Indications

Due to its spasmolytic and ulcer-relaxing action, Dactil OB is indicated:

  • as a part of combined therapy in the case of threatened miscarriage and preterm birth.
  • treatment of dysmenorrhea.

Dosage and administration

Treatment should be started as soon as the diagnosis of preterm birth or miscarriage has been established. The dose regimen is 1 tablet of Dactil Ob every 6 hours until uterine hypertonia is controlled. Dactil Ob should be withdrawn when the doctor considers it is right or until 36 or 38 gestation week. In the case of dysmenorrhea, 1 tablet every 8 hours is recommended.

Contraindications

Like other anticholinergic drugs, Dactil Ob should not be prescribed for patients in the following conditions:

  • hypersensitivity to the drug components;
  • narrow-angle glaucoma because there is a risk of acute glaucoma crisis due to closure of the iridocorneal angle;
  • paralytic ileus, as it can get worse;
  • tachycardia;
  • hyperthyroidism, due to the risk of cardiac decompensation;
  • pyloric stenosis because there may be a risk of complete occlusion;
  • acute pulmonary edema;
  • myocardial infarction;
  • severe hepatic impairment, since the effects are increased and prolonged;
  • severe renal failure, as the effects are increased and prolonged;
  • Down’s Syndrome;
  • the age under 18 years olf;
  • lactation.

Side effects

In patients with coronary insufficiency, the drug administration can cause tachycardia, arrhythmia and myocardial infarction. In the case of chronic bronchitis, the administration of Dactil Ob may cause depletion of bronchial secretions associated with the formation of mucus plugs.

In general, be cautious when administering antimuscarinic drugs to patients with diarrhea.

Overdose

Common symptoms of an overdose are:

  • high doses of piperidolate hydrochloride cause:
  • agitation;
  • auditory and visual hallucinations;
  • atrioventricular block;
  • cycloplegia;
  • delirium;
  • tempospatial disorientation;
  • excitement;
  • fever;
  • photophobia;
  • orthostatic hypotension;
  • paranoid ideas;
  • instability;
  • slowness in generating ideas;
  • micropsia;
  • mydriasis;
  • attention disorders;
  • drowsiness.

Treatment: In case of overdose, it is suggested to administer activated carbon (to reduce absorption) before gastric lavage, as well as supportive therapy as necessary.

Treatment of symptoms may require temperature control, as well as administration of diazepam to control agitation and seizures.

Phenothiazides should not be used, as they exacerbate antimuscarinic effects.

Interaction

The effect of atropine and Dactil Ob can be increased by the concomitant administration of other drugs with antimuscarinic properties such as amantadine, H1-histaminergic blockers, butyrophenones, and phenothiazines, as well as tricyclic antidepressants. The combined use of Dactil Ob increases the likelihood of adverse effects such as paralytic ileus, urinary retention, and blurred vision.

Dactil Ob may affect the absorption of other medications because they reduce gastrointestinal motility. This can increase the bioavailability of poorly soluble drugs.

When administering antimuscarinic drugs, the intestinal degradation of levodopa increases, so its serum concentrations decrease.