Dafloxen F (Paracetamol, Naproxen)

Active Ingredient: Naproxen, Paracetamol
Dosage: 275 mg/300 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 16 tablets per pack

Dafloxen-F is an oral drug that has analgesic, antipyretic and weak anti-inflammatory action. It is used to treat weak and moderate pain due to headache, migraine, toothache, neuralgia, algomenorrhea, trauma, burns, myalgia. It can also reduce fever in infectious and inflammatory diseases. The drug contains 2 active ingredients: naproxen and paracetamol.

Dafloxen F is curenlty out of stock but you can order a similar drug based on Naproxen.

Indications

Dafloxen F is an analgesic, antipyretic and non-steroidal anti-inflammatory drug. It is used as an analgesic for painful conditions: musculoskeletal, otic, pharyngeal, postoperative, postpartum, dental and traumatic. It is also used in the symptomatic treatment of pain and fever, as an adjuvant to antibiotic therapy in respiratory infections and those that present with inflammation and pain.

Dosage and administration

Tablets are taken orally.

Adults: two tablets as the start of treatment, then one tablet every 6-8 hours.

Contraindications

Do not use Dafloxen F if you have hypersensitivity to naproxen sodium and/or paracetamol.

Another contraindication is the use in patients with a history of the asthmatic syndrome, nasal polyps, hives or angioedema secondary to the use of acetylsalicylic acid and other anti-inflammatory agents.

The use of the medicine should be avoided in patients with hepatic or renal impairment, granulocytopenia or agranulocytosis, coagulation disorders, active peptic disease, anemia, systemic lupus erythematosus or under treatment with anticoagulants. Do not use the drug if you suffer from alcoholism or have a history of gastrointestinal bleeding.

Side effects

In some cases, Dafloxen F can cause adverse effects: abdominal discomfort, peripheral edema, vomiting, nausea, headache, tinnitus and vertigo have been reported; very rarely aseptic meningitis, colitis, gastrointestinal ulcerations, dermatitis, angioedema, alopecia, photosensitivity reactions, aplastic and hemolytic anemia, skin rashes, stomatitis, granulocytopenia, hematuria, fulminant hepatitis, hearing loss, cognitive and mental concentration disorders, insomnia, eosinophilic nephropathy or pneumonitis, bleeding and / or gastrointestinal perforation, thrombocytopenia, vasculitis, toxic epidermolysis (Stevens-Johnson syndrome) and seizures.

It is possible that patients with compromised cardiac function may have a higher risk of water and / or saline retention, so the sodium content of the drug should be considered. High doses of the drug can cause renal failure with uremia. Prolonged use of the drug may increase the risk of renal adverse effects.

Overdose

Overdose is characterized by vertigo, heartburn, nausea, vomiting, occasional seizures, abdominal pain, pale skin and metabolic acidosis. In the presence of these signs and symptoms, gastric lavage and general supportive measures are indicated. Activated carbon at a dose of 0.5 mg/kg of weight can be used.

Interaction

Concomitant use of glucocorticoids, ACTH, other anti-inflammatories and alcohol, may increase the risk of gastrointestinal adverse effects. The use with oral anticoagulants, heparin, hypoglycemic agents or insulin, can potentiate their effect, so close monitoring and dosage adjustments are required. Diuretics, antihypertensives and phenobarbital may decrease the effect of Dafloxen F. The use with medications that can cause blood dyscrasias or bone marrow depression increases the potential risk of serious hematologic effects. Concomitant use of the drug with any other nephrotoxic medicine or platelet aggregation inhibitor may result in a greater number and severity of adverse effects. The use with zidovudine is contraindicated.