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Dolo Neurobion Forte (Diclofenac; Vitamin B1; Vitamin B6; Vitamin B12)

Active Ingredient: Diclofenac; Vitamin B1; Vitamin B6; Vitamin B12
Dosage: 25, 50 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 10 per pack

Dolo Neurobion Forte belongs to an analgesic-antipyretic class. It provides an analgesic, antipyretic and weak anti-inflammatory effect. The mechanism of action lies in the suppression of prostaglandin synthesis. It affects the thermoregulation center in the hypothalamus and enhances heat transfer.

Dolo Neurobion Forte is currently unavailable but you can find a similar medication on this page.


Dolo Neurobion Forte tablets are used to treat:

  • Painful and painful inflammatory states of a diverse cause;
  • Degenerative forms of painful inflammatory and inflammatory activity of rheumatism, such as osteoarthritis, spondyloarthritis, chronic polyarthritis, ankylosing spondylitis, an acute attack of gout, extra-articular rheumatism.

Dosage and administration

Dosage for adults: Adults can take 1 tablet 1 to 3 times daily.


Do not use Dolo Neurobion Forte if you have any of the following conditions/diseases:

  • hypersensitivity to the components of the drug;
  • polycythemia vera;
  • hereditary optic nerve atrophy;
  • gastroduodenal acidopeptic ulcer;
  • bronchial asthma attacks, urticaria or acute rhinitis;
  • a history of bleeding from the digestive tract;
  • pregnancy, lactation and children severe hypertension;
  • cytopenias.

Side effects

In rare cases, the drug can cause the following side effects:

  • various gastrointestinal discomforts (nausea, vomiting, diarrhea), gastrointestinal bleeding and exacerbation of ulcerative colitis.
  • headache, vertigo, fatigue and more rarely tinnitus, insomnia, irritability or seizures;
  • rashes or hives and Stevens-Johnson syndrome, alopecia or photosensitivity;
  • acute renal failure, hematuria, nephrotic syndrome and interstitial nephritis;
  • various degrees of liver dysfunction, including jaundice or anicteric hepatitis.
  • anemia, leukopenia, thrombocytopenia, pancytopenia, anaphylactoid reactions.


To decrease drug absorption, gastric lavage should be performed or vomit induced. Also, the administration of antacids or alkalinizes of the urine can be used to increase the excretion of the drug. The use of diuretics is not effective in cases of diclofenac overdose.

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On the contrary, hemodialysis can be effective in reducing serum concentrations of diclofenac.

In severe cases, volume expanders can be used to treat hypotension and diazepam for seizure control. In hypoprothrombinemia, vitamin K is administered intramuscularly.

The patient’s vital functions should be carefully monitored and glucocorticoids should be used if there is evidence of renal damage (nephritis or nephrotic syndrome), thrombocytopenia, hemolytic anemia and severe skin reactions due to hypersensitivity.

In isolated cases, peripheral sensory neuropathy may occur, reversing with the suspension of drug administration. Nephrotoxicity may occur after prolonged consumption of 200 mg of pyridoxine per day and the symptoms of dependence developed by adults receiving daily doses greater than 200 mg have become apparent.


  • Concomitant treatment with digoxin or lithium preparations may raise your serum levels;
  • Dolo Neurobion Forte can reduce the action of diuretic and antihypertensive agents; it can cause hyperkalemia when combined with potassium-sparing diuretics;
  • The drug increases the hypoglycemic effect of oral sulfonamide-type antidiabetics;
  • Concomitant use of glucocorticoids and other anti-inflammatory drugs increases the risk of gastrointestinal bleeding. Acetylsalicylic acid reduces the serum concentration of diclofenac;
  • Concomitant use of methotrexate raises its concentration;
  • Simultaneous use with anticoagulants requires convenient control of the coagulation state;
  • Patients treated with levodopa should take preparations containing high doses of vitamin B6.