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Erispan Compuesto (Loratadine, Betamethasone)

Active Ingredient: Loratadine, Betamethasone
Dosage: 100 mg / 5 mg
Route of Administration: Oral
Dosage Form: Solution
Quantity per package: 100 ml
Availability: Out of Stock

Why is Erispan Compuesto not used in the USA?

Erispan Compuesto (allergy medication) is not used in the United States primarily due to FDA regulations, which may not have approved the combination of Loratadine and Betamethasone for use in treating allergies. The U.S. has strict guidelines and approval processes for combination drugs, focusing on the efficacy and safety of such combinations before they can be marketed.

Alternative Drugs Used in the USA

Below is a list of drugs that are popular in the United States for treating the same diseases and symptoms as Erispan Compuesto, divided into groups based on their main active ingredients:

Antihistamines

These medications help reduce the symptoms of allergies:

Corticosteroids

Leukotriene Receptor Antagonists

What is Erispan Compuesto?

Erispan Compuesto is a combination medication that contains Loratadine, Betamethasone. It is prescribed for allergy symptoms’ treatment. Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body, which can produce symptoms of sneezing, itching, watery eyes, and runny nose. Betamethasone is a corticosteroid that helps reduce inflammation. Together, these active ingredients make Erispan Compuesto effective for treating allergy symptoms such as severe allergic reactions, skin allergies, and chronic urticaria (hives).

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Indications

Erispan Compuesto is indicated for the relief of the inflammatory and pruritic manifestations that characterize some atopic dermatosis, angioedema, urticaria, seasonal and perennial allergic rhinitis; food and drug allergic reactions, seborrheic dermatitis, neurodermatitis, allergic asthma, allergic eye manifestations such as conjunctivitis and iridocyclitis and allergic reactions to insect bites.

The purpose of this combination is the elimination of inflammation through the action of betamethasone and pruritus through the action of loratadine.

Popularity and Use in Specific Countries

Erispan Compuesto is popular in several Latin American countries, such as Mexico and Colombia. The popularity in these regions can be attributed to the high prevalence of allergic diseases due to diverse environmental factors that include high levels of air pollution, diverse flora, and specific regional allergens. It is also relatively affordable, which makes it accessible to a larger portion of the population in these countries.

Dosage and administration

The drug is taken orally. Dose: Children 4 to 6 years of age: Weighing 30 kg or less: Half (½) teaspoon (2.5 ml) twice a day, every 12 hours. Dose: Children 6 to 12 years of age: Weighing more than 30 kg: One teaspoon (5 ml) twice a day, every 12 hours.

The specific dosages of Erispan Compuesto vary based on the severity of the condition being treated, the age of the patient, and other individual health factors. Typically, it is available in the form of tablets and sometimes as an injectable solution.

Contraindications

Erispan Compuesto is contraindicated in patients with systemic fungal infections and in those with hypersensitivity to any of its components or to drugs of similar chemical structures, pregnancy and lactation.

Side effects

The most commonly reported adverse effects include fatigue; headache; drowsiness; dry mouth; gastrointestinal disorders such as nausea and gastritis; allergic symptoms such as rashes; fluid and electrolyte disorders, sodium retention, loss of potassium, hypocalcemic alkalosis, fluid retention, CHF in sensitive patients and hypertension; musculoskeletal, muscle weakness, corticosteroid myopathy, loss of muscle mass, worsening of myasthenic symptoms in myasthenia gravis; osteoporosis, vertebral fractures, compression, aseptic necrosis of the femoral and humeral heads, pathological fracture of the long bones and tendon rupture; gastrointestinal, peptic ulcer with the possibility of further perforation and bleeding, pancreatitis, abdominal distension and ulcerative esophagitis; dermatological, impaired wound healing, skin atrophy, fragile and thin skin, petechiae and ecchymosis, facial erythema, increased sweating, suppression of reactions such as allergic dermatitis, urticaria and angioneurotic edema; neurological, seizures, increased intracranial pressure with papilledema (cerebral pseudotumor), usually, after treatment, vertigo and headache; endocrine, menstrual irregularities, development of cushingoid status, suppression of intrauterine fetal or childhood growth, lack of secondary response of the adrenal cortex or pituitary, particularly, in times of stress, such as trauma, surgery or condition of enf, reduction of carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements of insulin or oral hypoglycemic agents in diabetic patients; ophthalmic, posterior subcapsular cataracts, increased intraocular pressure, glaucoma and exophthalmos; metabolic, negative nitrogen balance due to protein catabolism; psychiatric, euphoria, violent mood swings, from severe depression to frankly psychotic manifestations, personality changes, exaggerated irritability and insomnia; others, anaphylactoid and hypersensitivity reactions and hypotensive or shock-like reactions.

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Overdose

Erispan Compuesto is a combined product, so the potential toxicity of each of its components must be considered. An overdose may cause drowsiness, tachycardia and headache. If necessary, the treatment should be started immediately (symptomatic and adjuvant). Treatment: Vomiting should be induced even if emesis has occurred spontaneously. Vomiting induced pharmacologically with the administration of syrup of ipecac is the preferred method. However, vomiting should not be induced in patients with an altered state of consciousness. Adequate fluid intake should be maintained and serum and urinary electrolytes monitored, paying particular attention to sodium and potassium balance.

Interaction

Loratadine: an increase in plasma concentrations of loratadine has been reported after concomitant administration of ketoconazole, erythromycin or cimetidine in controlled clinical studies, but no clinically significant changes (including electrocardiographic) have been observed; Precaution should be exercised when other drugs that inhibit liver metabolism are co-administered.

Betamethasone: the concomitant use of phenobarbital, rifampicin, diphenylhydantoin or ephedrine may increase corticosteroid metabolism by decreasing its therapeutic action.

Patients who co-administered a corticosteroid and an estrogen should be observed for the possible increase in corticosteroid effects. Simultaneous administration of corticosteroids with diuretics that cause increased potassium elimination could increase hypokalemia. Concomitant use of corticosteroids with cardiac glycosides may increase the possibility of arrhythmias or digital toxicity associated with hypokalemia. Corticosteroids may increase potassium depletion caused by amphotericin B. Concomitant use of corticosteroids with coumarin-like anticoagulants may increase or decrease the anticoagulant effects, possibly requiring dose adjustment. The combined effects of NSAID drugs or alcohol with corticosteroids could increase the incidence or increase the severity of gastrointestinal ulcers. Corticosteroids can reduce blood salicylate concentrations. The ASA should be used carefully in conjunction with corticosteroids in case of hypoprothrombinemia. When corticosteroids are administered to diabetics, an adjustment of the antidiabetic drug may be required. Concomitant use of corticosteroids with somatropin may inhibit the response to somatropin.

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Administration of Erispan Compuesto should be suspended approximately 48 hours before performing skin test procedures since these drugs can prevent or lessen reactions that would otherwise be positive for dermal reactivity indicators. Corticosteroids can alter the results of the tetrazolyl nitro blue test for bacterial infections and produce false ones.