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Espaven M.D. (Metoclopramide, Dimethicone)

Active Ingredient: Metoclopramide, Dimethicone
Dosage: 40 mg/10 mg
Route of Administration: Oral
Dosage Form: Capsules
Quantity per package: 20 capsules per pack

Espaven M.D. is a combination of metoclopramide and dimethicone. It is used to prevent postoperative nausea and vomiting, induced by radiotherapy or delayed chemotherapy-induced. It is also used to treat nausea and vomiting including those induced by acute migraine; in children and adolescents.

Espaven M.D. is out of stock but you can order a similar medication based on metoclopramide.


  • Gastroesophageal reflux with or without delay of gastric emptying, gastric hypotonia;
  • Postprandial fullness, nausea and vomiting, hiatal hernia, diabetic and post-surgical gastroparesis;
  • Emesis prophylaxis induced by chemotherapy.

Dosage and administration

Take one capsule orally, 30 minutes before each meal or before bedtime.


  • Hypersensitivity to the components of the formula;
  • Mechanical obstruction or gastrointestinal perforation;
  • Duodenal ulcer;
  • Bleeding from the digestive tract;
  • Pheochromocytoma;
  • Seizure disorders.

Espaven M.D. is also contraindicated as a prophylactic antiemetic in patients with breast cancer under chemotherapy.

Side effects

In rare cases, Espaven M.D. can cause the following adverse reactions: vertigo, asthenia, insomnia, headache, dysphoria, dyskinesias, diarrhea, dry mouth and hypersensitivity reactions, galactorrhea.


Doses up to 1 g / day have been administered without toxic effects. Overdose of Espaven M.D. can cause vertigo, ataxia, agitation, hyperexcitability, extrapyramidal reactions, oculogyric seizures and seizures. Treatment: gastric lavage and supportive care, or central action anticholinergics. Symptoms of overdose disappear within 24 hours.


Espaven M.D. can delay the absorption of paracetamol, acetylsalicylic acid, diazepam, levodopa, lithium and tetracyclines. It potentializes CNS depressant barbiturates, anesthetics and alcohol. It antagonizes anticholinergics. It can increase the appearance of extrapyramidal reactions if it is associated with butyrophenone and phenothiazines.

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