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Gynotran (Metronidazole, Miconazol)

Active Ingredient: Metronidazole, Miconazol
Dosage: 750 mg / 200 mg
Route of Administration: Intravaginal
Dosage Form: Suppositories
Quantity per package: 7
Availability: Out of stock

Why is Gynotran not sold in the USA?

Gynotran is not used in the USA, primarily because each active ingredient (Metronidazole and Miconazole) is typically used separately under different brand names and formulations. The FDA has strict regulations regarding combination medications, and there may be preferred formulations already available.

What are Similar Drugs Available in the USA?

Below are drugs available in the USA that are used to treat similar vaginal infections:

Antifungal Medications:

Antibacterial/Antiprotozoal Medications:

What is Gynotran?

Gynotran belongs to an antibiotic group prescribed to fight bacterial vaginal infections. It is released in the form of suppositories. It contains Metronidazole and Miconazole, combining an antibacterial and an antifungal agent.


Gynotran is usually administered as a vaginal ovule (suppository) or cream. The common dosage involves inserting one ovule or a specified amount of cream into the vagina once a day, typically at bedtime, for a duration of 7 to 14 days depending on the severity of the infection and medical guidance.

Popularity and Use in Other Countries

Gynotran is popular in countries where there is a higher prevalence of combined bacterial and fungal vaginal infections, often due to climatic conditions that favor these infections, such as tropical and subtropical regions. These include countries in Latin America and parts of Southeast Asia.

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Side Effects

Gynotran, containing both Metronidazole and Miconazole, may cause several side effects, which vary from mild to potentially serious. Common side effects include:

  • Vaginal irritation or itching
  • Mild burning sensation upon application
  • Increased vaginal discharge

Less common but more serious side effects can include:

  • Allergic reactions, such as rash, itching, swelling (especially of the face, lips, tongue), severe dizziness, or trouble breathing.
  • Pelvic pain
  • Headache
  • Metallic taste in the mouth (more commonly associated with Metronidazole)
  • Urinary tract symptoms, such as pain during urination or urgent need to urinate


Gynotran is contraindicated in patients with certain conditions. These include:

  • Allergy to Metronidazole, Miconazole, or any other ingredients in the product
  • First trimester of pregnancy (due to the potential risks associated with Metronidazole)
  • Use of alcohol or products containing propylene glycol during treatment and at least 3 days after treatment with Metronidazole (to avoid possible disulfiram-like reactions, such as abdominal cramps, nausea, vomiting, headaches, and flushing)

Drug Interactions

Gynotran can interact with several other drugs, potentially altering their effects. Notable interactions include:

  • Anticoagulants (e.g., Warfarin): Metronidazole can enhance the effect of anticoagulants, increasing the risk of bleeding.
  • Alcohol: Drinking alcohol during treatment with Metronidazole can cause disulfiram-like reactions, which are unpleasant and potentially harmful.
  • CYP450 enzyme inhibitors (such as certain antifungals like Ketoconazole): These can increase the levels of Metronidazole in the body, potentially leading to increased side effects.
  • Lithium: Metronidazole can increase the levels of lithium in the blood, potentially leading to lithium toxicity.
  • Phenobarbital and other enzyme inducers: These can decrease the effectiveness of Metronidazole by increasing its breakdown in the liver.

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