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Donodol (Clonixin)

Active Ingredient: Clonixin
Dosage: 250 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 10 tablets
Availability: Out of stock

Donodol is an NSAID with predominant analgesic action. It inhibits the synthesis of prostaglandins in peripheral tissue by inhibiting cyclooxygenase. The drug has analgesic and anti-inflammatory activity in cases of symptomatic and visceral pain. It is used to treat post-surgical pain in gynecology, orthopedics, urology and general surgery, pain from trauma in general, dislocations, sprains, fractures, myalgias, myositis, periarthritis and neuritis, dysmenorrhea, mastalgia, adnexitis, puerperal pain, episiotomy, toothache, tooth extractions, colics, cholelithiasis, proctological surgery, hemorrhoids, rheumatic pains, gout, bland tissue disorders, otalgia, sinusitis, herpes zoster, neuralgia, neuritis; cystitis, prostatitis, urolithiasis, pain of cancerous origin.

Donodol is currently unavailable but you can find other effective pain-relievers on this page.


Donodol is indicated as an analgesic and anti-inflammatory in conditions in which somatic and visceral pain are involved, such as:

  • Surgery: Post-surgical pain in gynecology, orthopedics, urology and general surgery;
  • Traumatology: Pain due to trauma in general, dislocations, sprains, fractures, myalgias, myositis, periarthritis and neuritis;
  • Gynecology: Dysmenorrhea, mastalgias, adnexitis, puerperal pain, episiotomy, etc.;
  • Dentistry: Odontalgias, dental extractions, etc.;
  • Gastroenterology: Colic, cholelithiasis, proctological surgery, hemorrhoids;
  • General medicine: Rheumatic pain, gout, soft tissue conditions, otalgia, sinusitis, shingles, neuritis, neuralgia.
  • Urology: Cystitis, prostatitis, urolithiasis;
  • Oncology: The clinical evaluation of the observed results indicates that this product is an alternative in the relief of pain of cancerous origin.

Dosage and administration

Route of administration: Oral. Take one or two tablets every 6-8 hours or as recommended by a doctor.


Donodol is contraindicated for use in patients hypersensitive to the components of the formula, in pregnancy, active peptic ulcer, gastrointestinal bleeding, megacolon, thyrotoxicosis, heart failure, acute abdomen, glaucoma, urinary tract obstruction due to prostatic hypertrophy, obstructive diseases of the gastrointestinal tract such as achalasia, pyloric stenosis, paralytic ileus, intestinal atony, ulcerative colitis, myasthenia gravis, and hiatal hernia associated with gastroesophageal reflux.

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Side effects

Some patients may experience nausea, vomiting and dizziness when the recommended dose of Donodol is exceeded or in people sensitive to the medication. If the discomfort is excessive, the treatment should be withdrawn. This drug can also cause dry mouth, accommodation disorders, constipation and pulse acceleration.


The doses of Donodol used and advised for treatment are far from the toxic dose. However, some patients may experience hypotension, tinnitus, vertigo and dizziness. In case of overdose, it is recommended to maintain permeable airways, correct vital signs, do gastric lavage and aspiration. Overdose of the parasympatholytic component of the drug can cause tachycardia, rapid breathing, hyperpyrexia, restlessness, confusion, and excitement. Massive overdose can cause high blood pressure with circulatory insufficiency, and respiratory depression. In case of overdose poisoning, empty the stomach by aspiration, administer diazepam or a short-acting barbiturate to control the excitation, and provide supportive treatment, which usually includes oxygen and artificial respiration, apply compresses of ice or sponges soaked in alcohol for hyperpyrexia (especially in children), introduce a bladder catheter and administer fluid.


Donodol does not alter the function of coagulation and does not interact with anticoagulant medications since Lysine Clonixinate does not interfere with coagulation as do other acidic analgesics. Because it has a minimal ulcer effect, the concomitant administration of the drug with potentially ulcerogenic medications should be taken into account in order to avoid intestinal aggression. The parenteral parasympatholytic component of the drug can interact and potentiate its effect by the action of tricyclic antidepressants, quinine, and amantadine, some antivirals, some antihistamines, butyrophenones, phenothiazines and derivatives.