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Samyr (Ademetionine)

Active Ingredient: Ademetionine
Dosage: 500 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 10, 20, 40 tablets per pack

Samyr is a dietary supplement. It helps support healthy moods, joints, and liver function.

Samyr is not available at the moment but you can search for alternatives here.


The drug is indicated in adults for the treatment of liver failure, alcoholic hepatitis, hepatic steatosis, intrahepatic cholestasis in pre-cirrhotic states and cirrhosis as well as in intrahepatic cholestasis of pregnancy.

Dosage and administration

The tablets should be swallowed and should not be chewed. For better absorption of ademethionine and a complete therapeutic effect, the tablet should be taken on an empty stomach. The tablets should be removed from the aluminum package at the time of use. If the tablets have a different color than white (due to the presence of holes in the aluminum wrap) it is recommended not to consume the product. The recommended daily dose of Samyr for the symptomatic relief of cholestasis and chronic liver disease, regardless of its etiology, is 1000 to 1500 mg orally.

Elderly: A sufficient number of studies have not been conducted in people over 65 to determine whether they respond differently to the drug. Reports of clinical experience have not identified differences in response between young and elderly patients. In general, the selection of the dose for an elderly patient should be done with caution, starting with the lowest dose, taking into account the decrease in liver, kidney or cardiac function frequent in this group of patients as well as diseases and / or therapies concomitant pharmacological.

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Children: The safety and efficacy of the use of Samyr in children have not been established.

Liver damage: Pharmacokinetic parameters are similar in healthy volunteers and in patients with chronic liver disease.

Kidney damage: No studies have been conducted in patients with kidney damage. Therefore caution is recommended when administering ademethionine in this group of patients.


Samyr is contraindicated for use in patients with known hypersensitivity to the active substance or to any active component of the formula.

Side effects

When used at recommended therapeutic doses, the drug is usually well tolerated. In some cases, it can cause anxiety, mild insomnia, nausea, headache, heartburn and diarrhea. In patients with manic depressive illness, the onset of a manic episode may precipitate.


There have been no reported cases of overdose in humans. No specific antidote is known. In case of overdose, general measures and maintenance of vital respiratory and cardiovascular functions are recommended.


Serotonin syndrome has been reported in patients taking Samyr and clomipramine. Therefore, although a potential interaction has been postulated, caution is recommended when ademethionine is co-administered with selective serotonin recapture inhibitors (SSRIs), tricyclic antidepressants (such as clomipramine), as well as herbal compounds or over-the-counter (OTC) containing tryptophan.