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Ulcoderma (Chloramphenicol, Collagenase)

Active Ingredient: Chloramphenicol, Collagenase
Dosage: 15 g
Route of Administration: Local
Dosage Form: Ointment
Quantity per package: 1 unit
Availability: Out of stock

Why is Ulcoderma not sold in the USA?

Ulcoderma is not used in the USA mainly because Chloramphenicol has been largely replaced by other antibiotics that pose fewer risks of side effects, such as bone marrow suppression. The FDA restricts the use of Chloramphenicol in topical medications due to these potential severe adverse effects.

Equivalent Drugs of Ulcoderma Sold in the USA

Antibiotics (for preventing or treating bacterial skin infections):

Anti-Infectives (for specific skin infections):

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What is Ulcoderma?

Ulcoderma is an ointment, which is used topically to treat problems related to wound healing and to prevent and combat skin infections. It has two components: collagenase (an enzyme) and chloramphenicol, a fairly effective antibiotic. The drug is used for the treatment of ulcers of the skin, which can be caused by deficient functioning of the venous system, (diabetes or pressure ulcer); burns (second or third degree); wounds that do not close, as in the sutures that open or separate, which prevents healing; abrasions, caused by rubbing or scraping, excoriations of the skin, ie areas in which part of the skin has been separated as a result of some friction or friction. The medication is applied directly on the skin of the affected area.


Treatment of skin infections

Dosage and administration

Ulcoderma Ointment should be applied as a thin layer covering the entire lesion surface. Generally, one application per day is sufficient, but if a physician considers that a more intense effect is required due to the characteristics of the lesion, it can be applied twice a day. It is recommended to previously moisten the lesion to soften them and facilitate the product action.

Popularity and Usage by Country

Ulcoderma is popular in countries with higher incidences of chronic wounds, such as diabetic ulcers, and where there is a significant need for effective topical treatments against bacterial infections. Countries with tropical climates, where skin infections are more prevalent due to the environment, also see higher usage. These countries might include parts of Southeast Asia, Africa, and Latin America, where healthcare systems heavily rely on effective and affordable treatments for common, yet potentially severe, skin conditions.

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Popularity and Use in Specific Countries

Ulcoderma is particularly popular in countries with higher incidences of chronic wounds, such as diabetic ulcers, and where there is a significant need for effective topical treatments due to the prevalence of infections in wounds. These countries often include those with limited access to advanced healthcare facilities or in tropical climates where the risk of infection is higher, such as parts of Africa, Asia, and Latin America.


Hypersensitivity to collagenase, chloramphenicol or both substances.

Side effects

Ulcoderma ointment is well-tolerated. Pain or burning may rarely manifest itself in the lesion. Depending on its intensity, a doctor will indicate the need to discontinue treatment or not.

Signs of local intolerance in the skin around the lesion, manifested by hyperemia or erythema, have also been reported.

In these cases, intolerance can decrease. It is better to protect the surrounding skin with paste or some similar agent.


There are no reports of overdosing or accidental intake. This ointment has no activity on healthy and unwounded skin, however local reactions of intolerance may occur. In these cases it is recommended to wash the area with neutral soap and establish a conservative therapy, considering it as contact dermatitis.

If accidental application occurs in mucous or conjunctiva, manifestations of local irritation may occur. Only irrigation with physiological solution or boiled water at the application site is recommended, to remove ointment. Subsequently, symptomatic management would be indicated.


Ulcoderma should not be used in the presence of antiseptics, heavy metals, hexachlorophene detergents, soaps or acidic solutions since collagenase activity will be inhibited. It should not be used locally with thyrotropin, gramicidin, and tetracyclines.