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Ampliron Duo (Amoxicillin, Clavulanate)

Active Ingredient: Amoxicillin, Clavulanate
Dosage: 875 mg / 125 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 14

Ampliron Duo contains Amoxicillin, Clavulanate. Its dosage 875 mg / 125 mg. It is prescribed to treat bacterial infections of different localization. Currently, this antibiotic containing these two components is unavailable. We offer you to search for the antibiotic category and find other antibiotics here.


It is a broad-spectrum antibiotic.

Ampliron Duo is indicated for the short-term treatment of the following bacterial infections:

  • infections of the upper respiratory tract (including nose, throat, and ear), for example, tonsillitis, sinusitis, otitis media;
  • infections of the lower respiratory tract, for example, acute and chronic bronchitis, lobar pneumonia and bronchopneumonia;
  • genitourinary infections, for example, cystitis, urethritis, pyelonephritis;
  • infections of the skin and soft tissues, for example, boils, abscesses, cellulite, wound infections;
  • osteoarticular infections, for example, osteomyelitis;
  • dental infections, for example, dentoalveolar abscesses.

Dosage and administration

Dose regimen: one tablet of Ampliron Duo every 12 hours.

The administration of Ampliron Duo is not recommended in patients under 12 years of age. Dosage in patients with hepatic impairment: Monitoring of liver function periodically is recommended.

Method of administration: this antibiotic is optimally absorbed before meals and this also reduces the possibility of gastrointestinal intolerance.

Treatment with Amprilon Duo should not exceed 14 days without patient reassessment.


Amoxicillin, Clavulanic Acid is contraindicated in patients with penicillin hypersensitivity. It is recommended to consider a possible cross-sensitivity with other β-lactam antibiotics, such as cephalosporins. History of jaundice or liver failure associated with the administration of penicillins or Amoxicillin, Clavulanic Acid is recorded.

Side effects

Side effects are rare and mainly of a mild and transient nature. Cases of diarrhea, indigestion, nausea, vomiting, pseudomembranous colitis and candidiasis have been recorded. Although cases of nausea occur very rarely, they are often associated with higher doses. In case gastrointestinal side effects occur, it is recommended to administer Ampliron Duo at the beginning of meals, to reduce these effects.

A moderate increase in AST and/or ALT has been recorded in patients treated with semi-synthetic penicillins, but the importance of this evidence is unknown.

Cases of hepatitis and cholestatic jaundice have rarely been reported which, however, can be severe and last several months. They have been found mainly in adult or elderly patients and a little more frequently in men.

These found cases associated with severe underlying diseases or concomitant medications. Sometimes urticarial and erythematous rashes and rarely erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, and exfoliative dermatitis can be caused by this antibiotic.

The effects on the central nervous system have rarely manifested. These include reversible hyperactivity, dizziness, headaches, and seizures. Seizures can occur when high doses are taken or there is a decrease in renal function.

The incidence of gastrointestinal side effects may be higher in children under 2 years old. As with other β-lactam antibiotics, transient leukopenia, thrombocytopenia and hemolytic anemia have rarely been reported.


If overdose happened, gastrointestinal symptoms, water, and electrolyte imbalance would be found. The treatment is symptomatical. It is mandatory to pay attention to the balance of water and electrolytes. Ampliron Duo can be excreted from the blood flow through hemodialysis.


  • Prolonged bleeding and prothrombin time have been observed in some patients treated with Ampliron Duo.
  • Ampliron Duo should be used with caution in patients undergoing anticoagulant treatment.
  • As with other broad-spectrum antibiotics, Ampliron Duo may decrease the effectiveness of oral contraceptives, so it is recommended to make the patient aware of.
  • Simultaneous use of probenecid and Ampliron Duo is not recommended. The renal tubular secretion of Amoxicillin is diminished by probenecid, resulting in increased and decreased Amoxicillin levels in the blood, but not clavulanic acid. Simultaneous use of allopurinol during treatment with this antibiotic may increase the rate of allergic skin reactions. There are no data on the concomitant use of this broad-spectrum antibiotic and allopurinol.