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Dimegan-D (Loratadine, Phenylephrine)

Active Ingredient: Loratadine, Phenylephrine
Dosage: 5 mg/20 mg
Route of Administration: Oral
Dosage Form: Capsules
Quantity per package: 20 capsules per pack
Availability: Out of Stock

Why Dimegan-D Is Not Used in the USA

The combination of Loratadine and Phenylephrine in Dimegan-D may not be used in the USA due to stringent FDA regulations concerning the safety and efficacy of combined drugs. The U.S. market has strict guidelines on combination medications, especially those containing decongestants, due to concerns about potential side effects such as increased blood pressure. Moreover, the U.S. has a wide range of alternative medications that are already approved and widely used for similar conditions.

Equivalent Drugs Sold in the USA

For Allergic Rhinitis and Nasal Congestion

Each of these alternatives provides effective relief from allergy symptoms and is widely available across the United States, complying with FDA regulations and offering patients reliable options for managing their conditions.

What is Dimegan-D?

Dimegan-D is an antihistamine consisting of loratadine and phenylephrine. It is usually used to treat allergies, in particular allergic rhinitis, nasal congestion and nasal pruritus. It reduces the swelling of the blood vessels in the nasal passages by blocking histamine.

See also  Bronar (Loratadine)

Indications

Dimegan-D is indicated in the symptomatic treatment of allergic rhinitis, nasal congestion, and nasal eye pruritus.

Dosage and administration

Adults and children over 12 years old: 1 capsule every 12 hours. It’s important for patients to follow dosage instructions provided by their healthcare provider to avoid potential side effects from overuse, especially those related to the decongestant component.

Where is Dimegan-D Popular?

Dimegan-D is popular in countries where seasonal allergies are prevalent and where there is a high demand for over-the-counter remedies that can quickly alleviate symptoms. This includes:

  • Latin America: Countries such as Mexico, where environmental factors such as pollution and seasonal allergens are significant, find medications like Dimegan-D popular due to their effectiveness in managing allergy symptoms.
  • Southeast Asia: Similar to Latin America, countries in this region have high rates of respiratory allergies due to urban pollution and high pollen counts, making effective allergy medications sought after.

Contraindivations

  • Hypersensitivity to the components of the drug;
  • Treatment with MAO inhibitors;
  • Narrow-angle glaucoma;
  • Urinary retention;
  • Severe hypertension;
  • Severe coronary artery disease and hyperthyroidism;
  • Stenosis peptic ulcer;
  • Diabetes mellitus.

Side effects

Dimegan-D is well-tolerated at therapeutic doses. However, it can cause:

  • severe hypertension;
  • headache;
  • vomiting;
  • reflex bradycardia.

Fatigue, headache, drowsiness, dry mouth, nausea, gastritis, rash, insomnia and rarely alopecia, anaphylaxis or liver disorders may come over.

Elderly patients are more predisposed to the hypertensive and bradycardic effects of Dimegan-D, so they may have reduced cardiac output as a result of sinus bradycardia, increasing the risk of possible heart failure.

Overdose

In the event that overdose occurs, general symptomatic treatment should be started immediately. So far only tachycardia, headache, and drowsiness have been reported as symptoms of an overdose. Hemodialysis is ineffective.

See also  Dimegan D (Loratadine, Phenylephrine)

Interaction

Concomitant use with Ketoconazole, Erythromycin and Cimetidine has claimed an increase in Loratadine concentrations. Beta-blockers can increase the vasoconstrictor effects of phenylephrine. MAO inhibitors can prolong and intensify the pressor effects of Phenylephrine as well as Oxytocin.