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Dimegan-D (Loratadine, Phenylephrine)

Active Ingredient: Loratadine, Phenylephrine
Dosage: 5 mg/20 mg
Route of Administration: Oral
Dosage Form: Capsules
Quantity per package: 20 capsules per pack

Dimegan-D is an antihistamine consisting of loratadine and phenylephrine. It is usually used to treat allergies, in particular allergic rhinitis, nasal congestion and nasal pruritus. It reduces the swelling of the blood vessels in the nasal passages by blocking histamine. Dimegan-D is currently out of stock. We may offer an analog of this anti-allergic drug – Claritin.

Indications

Dimegan-D is indicated in the symptomatic treatment of allergic rhinitis, nasal congestion, and nasal eye pruritus.

Dosage and administration

Adults and children over 12 years old: 1 capsule every 12 hours.

Contraindivations

  • Hypersensitivity to the components of the drug;
  • Treatment with MAO inhibitors;
  • Narrow-angle glaucoma;
  • Urinary retention;
  • Severe hypertension;
  • Severe coronary artery disease and hyperthyroidism;
  • Stenosis peptic ulcer;
  • Diabetes mellitus.

Side effects

Dimegan-D is well-tolerated at therapeutic doses. However, it can cause:

  • severe hypertension;
  • headache;
  • vomiting;
  • reflex bradycardia.

Fatigue, headache, drowsiness, dry mouth, nausea, gastritis, rash, insomnia and rarely alopecia, anaphylaxis or liver disorders may come over.

Elderly patients are more predisposed to the hypertensive and bradycardic effects of Dimegan-D, so they may have reduced cardiac output as a result of sinus bradycardia, increasing the risk of possible heart failure.

Overdose

In the event that overdose occurs, general symptomatic treatment should be started immediately. So far only tachycardia, headache, and drowsiness have been reported as symptoms of an overdose. Hemodialysis is ineffective.

Interaction

Concomitant use with Ketoconazole, Erythromycin and Cimetidine has claimed an increase in Loratadine concentrations. Beta-blockers can increase the vasoconstrictor effects of phenylephrine. MAO inhibitors can prolong and intensify the pressor effects of Phenylephrine as well as Oxytocin.

See also  Bronar (Loratadine)