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Letinnov (Ethinyl Estradiol, Levonorgestrel)

Active Ingredient: Ethinyl Estradiol, Levonorgestrel
Dosage: 0.15mg/0.03mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 21, 28 tablets per pack

Letinnov is an oral contraceptive that is used to prevent pregnancy. It is a combination of female hormones (ethinyl estradiol and levonorgestrel ) that prevent ovulation (the release of an egg from an ovary). It also causes changes in the cervical mucus and uterine lining, making it more difficult for sperm to enter the uterus and more difficult for a fertilized egg to attach to the uterus.

Letinnov is currently unavailable but you can order a good contraceptive alternative on this page.


  • Oral contraception;
  • Menstrual cycle disorders;
  • Ovarian rest.

Dosage and administration

Take 1 tablet per day orally, as indicated by your doctor.

To achieve a contraceptive effect, 28 tablets are taken in a row, in accordance with the instructions on the blister, usually in the evening.

Initial intake begins on the 1st day of the menstrual cycle for 28 consecutive days. Menstrual bleeding usually occurs after 3 days of using the tablets. Regardless of the end of menstruation, start the next package.

Each subsequent 28-day package is started without a break.

If you miss a pill, you should take it within the next 12 hours. Otherwise, you should continue taking the pills at a specific time of the next day, without taking the missed pill. If you miss tablets, the likelihood of sudden bleeding increases.

The indicated method of administration can be continued as long as pregnancy prevention is desired.


Letinnov is not used if the patient has hypersensitivity (allergy) to one of the components that make up the drug.

In addition, the use of this drug is contraindicated in:

  • breast cancer;
  • estrogen-dependent cancers;
  • vaginal bleeding of unknown etiology;
  • incurable endometrial hyperplasia;
  • venous thromboembolism;
  • arterial thromboembolic disorders (e.g., angina pectoris, myocardial infarction);
  • thrombophilia (for example, protein C, S or antithrombin deficiency);
  • high risk of developing venous or arterial thrombosis;
  • liver tumors of any etiology;
  • liver diseases, until the normalization of laboratory parameters of the functional state of the liver;
  • porphyria;
  • severe hypertriglyceridemia.

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Side effects

When using this drug, the patient can experience the following side effects:

  • increase in blood glucose, anemia, changes in body weight, hyperbilirubinemia;
  • headache, migraine, memory loss, confusion, dizziness, insomnia;
  • visual impairment;
  • nausea, vomiting, bloating, abdominal pain, constipation, dyspeptic symptoms, pancreatitis, jaundice, diabetes mellitus;
  • acne, seborrhea, itching;
  • arterial hypertension, tachycardia, varicose veins, hemorrhoids, other disorders of the CVS;
  • thrombosis, superficial thrombophlebitis, arterial hypotension;
  • allergies, weight gain;
  • cholangitis, cholecystitis, impaired liver function;
  • neoplasia of the mammary glands, pain in them;
  • anxiety, depression;
  • venous thromboembolism.

If you have any side effects, consult your doctor


If you took an excessive dose of ethinyl estradiol/levonorgestrel, contact your local health care provider immediately. Symptoms may include severe dizziness, nausea, vomiting, stomach pain, unusual drowsiness or tiredness, unusual vaginal bleeding.


  • Reduced contraceptive effectiveness: carbamazepine, eslicarbazepine acetate, felbamate, oxcarbazepine, phenytoin, primidone, rufinamide, topiramate, aprepitant, barbiturates, bosentan, vemurafenib, griseofulvin, nelfinavir, ritonavir, ritonavir, ritonavir potentiators modafinil, nevirapamine, rifampin, rifabutin, penicillins, tetracyclines St. John’s Wort;
  • Increased plasma concentrations of ethinyl estradiol: grapefruit juice, ascorbic acid, itraconazole, ketoconazole, voriconazole, fluconazole, etoricoxib, atazanavir, indinavir, atorvastatin, rosuvastatin, etravirine, paracetamol;
  • Decreased plasma concentrations: lamotrigine, paracetamol, clofibric acid, morphine, temazepam;
  • Increased plasma concentrations: cyclosporine, omeprazole, prednisolone, selegiline, theophylline, tizanidine, voriconazole;
  • Reduced effect of Letinnov: oral anticoagulants, however, enhance the action of acenocoumarol.