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Libertrim SII (Trimebutine, Simethicone)

Active Ingredient: Trimebutine, Simethicone
Dosage: 200 mg/75 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 24
Availability: Out of stock

Why Libertrim SII Is Not Used in the USA

Libertrim SII is not commonly used in the USA, likely due to FDA regulations that require rigorous testing and approval for combination drugs. Additionally, the medical community in the U.S. might prefer other established therapies that are widely researched and have a robust safety profile according to U.S. standards.

Equivalent Drugs Sold in the USA

Here are some drugs used in the United States to treat similar symptoms of gastrointestinal disorders:

For Irritable Bowel Syndrome

For Colitis and Other Gastrointestinal Pathologies

For Gas and Bloating

These medications provide options for treating various gastrointestinal issues in the U.S., focusing on individual symptoms and underlying conditions to offer targeted relief and effective management of these disorders.

What Is Libertrim SII?

Libertrim SII tablets are used to treat irritable bowel syndrome, acute and chronic colitis, spasmodic colitis, duodenitis and other pathologies. The drug is effective for the treatment of colic abdominal pain in case of constipation and/or diarrhea. In addition, it prevents and relieves flatulence, aerophagia, abdominal pain due to excess gas. It is a combination drug that contains Trimebutine and Simethicone. Trimebutine is an antispasmodic agent that works by regulating the rhythmic movement of the gut, making it particularly effective for managing symptoms of irritable bowel syndrome (IBS) and various forms of colitis. Simethicone is an anti-foaming agent that helps reduce bloating, discomfort, or pain caused by excess gas in the stomach and intestines.

See also  Ulsen (Omeprazole)


These tablets, due to their content of trimebutine and simethicone, are indicated in the treatment of irritable bowel syndrome, acute and chronic colitis, spasmodic colitis, functional colopathies, duodenitis and other pathologies that present with tone alterations and gastroesophageal motility and intestinal as gastroesophageal reflux and esophagitis. It is effective and well-tolerated in the treatment of colic, abdominal pain in case of constipation and / or diarrhea. In addition, it prevents and relieves flatulence, aerophagia, abdominal pain due to excess gas.

In What Countries Is Libertrim SII Used?

Libertrim SII is popular in:

  • Latin America: Countries like Mexico and Argentina where dietary habits and lifestyle factors contribute to a high prevalence of IBS and related gastrointestinal disorders.
  • Europe: Some European countries also use this medication, benefiting from its dual-action treatment for gastrointestinal discomfort.

The medication’s effectiveness in treating complex symptoms associated with gastrointestinal disorders makes it a preferred choice. Its availability and the general acceptance of combination therapies for such conditions enhance its popularity.

Dosage and administration

For oral use.

  • Adolescents: ½ tablet every 8 hours;
  • Adults: 1 tablet every 8 or 12 hours.

It is recommended to take the medicine 15 to 30 minutes before meals, for at least 4 to 8 weeks, at the doctor’s discretion.

The exact dosage may vary based on the severity of the symptoms and the specific medical advice provided by a healthcare professional.


  • Hypersensitivity to the active substances;
  • Myasthenia gravis;
  • Occlusion;
  • Intestinal perforation.

Side effects

In most cases, trimebutine, the active ingredient of Libertrim SII, has excellent tolerability. Only rarely have headaches or mild skin reactions been reported, which have not required suspension of treatment. Simethicone acts on the intestinal lumen so it is not absorbed. Trimebutin has a high clinical, blood and renal tolerability, which allows it to be used for a long time and that the doses are increased according to the requirements of the case and at the doctor’s discretion.

See also  Libertrim SDP (Trimebutine, Simethicone)


In case of poisoning due to overdose or accidental intake of Libertrim SII, gastric lavage, general measures and patient observation are recommended.


The reported studies and clinical experience with the use of trimebutine and simethicone show ample safety and tolerability. To date, there have been no reports of incompatibility in concomitant administration of the drug with antibiotics, antimicrobials, antiparasitic agents, NSAIDs, histamine H2 receptor antagonists, hypoglycemic agents, antihypertensives, benzodiazepines, among others.