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Obrydex (Tobramycin, Dexamethasone)

Active Ingredient: Tobramycin, Dexamethasone
Dosage: 10 mg
Route of Administration: Ocular
Dosage Form: Oinment
Quantity per package: 1 unit
Availability: Out of stock

Obrydex contains Tobramycin, Dexamethasone. It is prescribed to treat and prevent eye infections.

Obrydex is currently unavailable for purchase but you can select a similar medication here.


Obrydex is indicated in superficial infections of the eye accompanied by inflammation such as blepharitis, conjunctivitis, keratitis, dacryocystitis, keratoconjunctivitis, meibimianitis caused by susceptible bacteria. It is also used as an adjunct in the treatment of severe intraocular infections. It is also indicated for the control of postoperative or posttraumatic ocular inflammation and to prevent the infection of susceptible microorganisms.

Dosage and administration

Dose: in mild infections: 1 or 2 drops in the affected eye every 4 hours. In severe infections: 1 or 2 drops every 30 to 60 min. The frequency of administration is determined by a doctor.


  • Hypersensitivity to the components of the formula or to other aminoglycoside antibiotics;
  • Ocular tuberculosis;
  • Epithelial keratitis;
  • Fungal conditions;
  • Herpes simplex;
  • Purulent infections;
  • Viral keratoconjunctivitis;
  • Foreign body erosion;
  • Alkali burns;
  • Open-angle glaucoma;
  • Family history of the latter.

Side effects

In rare cases, Obrydex causes sensitization reactions: excessive tearing, pruritus, eye pain, edema of the eye and eyelid, conjunctival erythema. With excessive use, dotted keratitis can occur. Corticosteroids can cause increased intraocular pressure with glaucoma, cataracts, secondary infections, delayed healing and perforation of the eyeball if the cornea or sclera are thinned.


Overdosing may cause side reactions. Prolonged use of steroids can cause glaucoma, damage to the optic nerve, defects in the field of vision and subsequent subcapsular cataract formation. Accidental intake is not significant since the concentration is low in relation to the systemic medication; in any case, slight and temporary stomach discomforts may occur.

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Concomitant use of corticosteroids and Obrydex may mask clinical signs of infection by bacteria, fungi or viruses. Due to the presence of corticosteroids, hypersensitivity reactions to the antibiotic or other components of the formula can be suppressed.