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Robaxifen (Methocarbamol, Acetaminophen)

Active Ingredient: Methocarbamol, Acetaminophen
Dosage: 400 mg/350 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 24 tablets per pack
Availability: Out of stocl

Why is Robaxifen not available in the USA?

In the USA, Robaxifen is not typically used or available, likely due to the strict regulatory environment regarding drugs that contain pain relievers like acetaminophen combined with muscle relaxants. The U.S. has approved other formulations and combinations that are deemed safer or more effective by the FDA.

Similar Drugs Available in the USA

Since Robaxifen is not available in the USA, here are similar medications available that are used to treat similar symptoms of muscle spasms and pain:

Muscle Relaxants:

Pain Relievers:

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What is Robaxifen?

Robaxifen is an analgesic-antipyretic. The dug contains methocarbamol and acetaminophen (paracetamol). Thi combination drug can relieve pain with a skeletal muscle spasm in any region of the locomotor system. It is prescribed to treat headache, migraine, neuralgia, myalgia, algomenorrhea, toothache, pain in trauma, burns, fever in infectious and inflammatory diseases.


Robaxifen is indicated in physiotherapy and other measures to relieve discomfort associated with acute painful musculoskeletal conditions. The mode of action of Methocarbamol has not been clearly explored but could be related to sedative properties. Methocarbamol does not directly relax the muscles with active contraction in man.

Popularity and Use in Specific Countries

Robaxifen is particularly popular in several countries where it is readily available, and there is a demand for combination pain relief and muscle relaxant treatments. Here is a detailed list of countries where Robaxifen is popular and explanations for its usage:

  1. Mexico: Robaxifen is widely used due to its effectiveness in treating musculoskeletal pain, which is a common issue among the working population involved in physical labor.
  2. Colombia: The drug’s availability and effectiveness in managing pain and muscle spasms make it a preferred choice in Colombia, where access to comprehensive pain management solutions might be limited in rural areas.
  3. Argentina: Its popularity in Argentina can be attributed to the high prevalence of sports-related injuries and an aging population that experiences chronic pain and muscle spasms.
  4. Spain: Although European countries generally have strict medication regulations, Spain allows the use of Robaxifen, appealing to patients looking for effective treatments for acute musculoskeletal conditions.
  5. Philippines: The drug is popular in the Philippines, where the climate and lifestyle contribute to conditions requiring treatments for muscle pain and spasms.

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Dosage and administration

Route of administration: oral. Dose: adults and children over 12 years old: 2 tablets 3 times a day. Do not administer in children under 12 years old. Dosage might vary based on the severity of the symptoms and patient’s response to the initial treatment.


Hypersensitivity to any of the drug components.

Side effects

The most common side effects of Robaxifen are dizziness, faintness, and nausea. These side effects occur in approximately 4-5% of patients. Other less frequent reactions are:

  • drowsiness;
  • blurred vision;
  • headache;
  • fever;
  • allergic manifestations such as hives, itching, and rash.

Adverse reactions that have been associated with the use of paracetamol include:

  • dermatological reactions (skin rash and hives);
  • neutropenia;
  • thrombocytopenic purpura.

Rarely, laryngeal edema, angioedema, anaphylaxis, and agranulocytosis have been detected.


The information available on the acute toxicity of Robaxifen is limited. There are no definite cases recorded.


Robaxifen should be used with caution in patients with myasthenia gravis who are receiving anticholinesterase agents. This drug administered concomitantly with phenothiazine can cause severe hypothermia.