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XL-DOL (Paracetamol)

Active Ingredient: Paracetamol
Dosage: 500 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 20 tablets per pack

XL-DOL (Paracetamol) is an oral painkiller used to treat aches and pain. It can also be used to reduce fever. The drug takes up to an hour to work.

This product is no longer in stock but you can purchase a complete analog of XL-DOL.

Indications

The drug is used to relieve fever and pain of any etiology.

Dosage and administration

Tablets are intended for oral administration 1-2 hours after a meal and with plenty of fluids.

Adult patients (including the elderly), older children (from 12 years old) are prescribed 500-1000 mg with an interval of 4-6 hours. The maximum dose that can be taken per day is 4 g. The interval between doses of paracetamol tablets should not be less than 4 hours. In people with impaired liver / kidney function, with Gilbert syndrome, elderly patients, the total daily dose should be reduced or the interval between doses should be increased accordingly.

Preschool children (3–6 years old or 15–22 kg) are prescribed a dose of 250 mg x 4 times / day (1000 mg / day). Children under 9 years old (or up to 30 kg) are prescribed 1500 mg / day, divided into 4 doses. Children under 12 years old (or up to 40 kg) – 500 mg x 4 times / day (2000 mg / day). The interval between each dose of paracetamol tablets should not be less than 4 hours.

Do not exceed the above doses. It is not recommended to take these tablets for more than five days as an anesthetic and more than three days as an antipyretic medicine. An increase in a single dose or duration of treatment is allowed only under the supervision of a doctor.

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During prolonged treatment, it is necessary to control the blood picture (general blood test) and the functional state of the liver (liver tests).

Contraindications

  • Hypersensitivity to paracetamol;
  • Severe hepatocellular insufficiency;
  • Viral hepatitis.

Side effects

In recommended doses, XL-DOL is generally well tolerated and rarely causes adverse reactions. In rare cases, patients experience allergic manifestations (skin rashes, redness, urticaria, itching, angioedema), multiform exudative erythema (including Stevens-Johnson syndrome), nausea, Lyell’s syndrome (allergic bullous dermatitis), dizziness, pain in the pancreas, increased activity of liver enzymes, decay of liver tissue, endocrine system disorders (hypoglycemia – falling sugar levels), thrombocytopenia (decrease in platelet count), agranulocytosis (decrease in number granulocytes), insomnia.

With prolonged use of large doses of paracetamol, the likelihood of impaired liver, kidney, and hematopoiesis increases.

Overdose

Signs of an overdose: pain in the pancreas, vomiting, pale skin, lack of appetite. After 1–2 days, signs of hepatonecrosis (destruction of the liver) may appear, the severity of which directly depends on the degree of overdose. In the most severe cases, liver failure, coma develops.

There is a specific antidote – N-acetylcysteine.

If you suspect an overdose of XL-DOL, you should immediately seek medical help. The toxic effect of paracetamol is observed in adults after taking a dose of more than 10-15 g.

Treatment of an overdose: the patient should undergo an emergency gastric lavage (during the first four hours after poisoning), take sorbents (for example, activated charcoal). 8–9 hours after the suspected overdose, administration of solutions (unitiol, precursors of glutathione-methionine) is indicated, and a day later – N-acetylcysteine. The doctor determines the need for additional therapeutic measures (continued administration of methionine, intravenous administration of N-acetylcysteine) depending on the time elapsed after administration, as well as on the concentration of paracetamol in the plasma.

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Interaction

Avoid taking XL-DOL with any of the following drugs and substances:

  • oral anticoagulants;
  • alcohol, isoniazid;
  • anticonvulsants;
  • estrogens;
  • loop diuretics, lamotrigine, zidovudine;
  • probenecid, isoniazid, propranolol;
  • anticholinergics, cholestyramine;
  • metoclopramide, domperidone;
  • rifampicin;
  • chloramphenicol.