Dioxaflex Duo (Diclofenac, Pridinol)

Active Ingredient: Diclofenac, Pridinol
Dosage: 50/4 mg
Route of Administration: Oral
Dosage Form: Tablets
Quantity per package: 30 pills per pack

Dioxaflex Duo is a muscle relaxant that is used as an antiparkinsonian and anticholinergic drug.

Dioxaflex Duo is currently out of stock but you can buy another Diclofenac-based medication here.

Indications

• Painful inflammatory processes with muscle contracture component;
• Rheumatic joint and extra-articular conditions;
• Fibrositis, myalgia, low back pain, torticollis, trauma, sprains, muscle tears.

Dosage and administration

The dose should be established individually according to the patient’s medical criteria and clinical picture.

As a guideline, the following doses are recommended:

Adults: Usual dose: 1 tablet of Dioxaflex Duo every 12 hours. Maximum dose: 3 tablets per day, divided into 3 doses (every 8 hours). The tablets can be taken before, during or after light meals, preferably with 1 full glass of water or another non-alcoholic beverage.
Administration together with large meals may decrease the rate of absorption of active substances. The duration of treatment will be determined according to medical criteria according to the type and evolution of the condition. In patients weighing less than 60 kg the maximum total daily dose should be reduced.

Pediatric Use: This pharmaceutical form is not suitable for children.

Contraindications

• Hypersensitivity to diclofenac, pridinol;
• Active gastroduodenal ulcer;
• Children;
• Asthmatic patients with a history of acute precipitation of asthma crisis, rhinitis or urticaria secondary to ASA or other drugs with inhibitory action on the synthesis of prostaglandins;
• Severe cardiovascular disease, heart failure, ischemic heart disease;
• Narrow-angle glaucoma;
• Bladder or intestinal obstructive disorders;
• Tachyarrhythmias;
• Megacolon and acute lung edema.

Side effects

In rare cases, Dioxaflex Duo can cause epigastralgia, nausea, abdominal pain, constipation, diarrhea, headache and dizziness; decreased sweating, skin rash, accommodation disorders, increased intraocular pressure, dry mucous membranes, tachycardia, voiding difficulty, psychomotor excitation and / or hallucinations.

Overdose

No cases of untreated overdose with Diclofenac + Pridinol have been reported so far. Overdose may cause an increase in the incidence or severity of any of the known adverse reactions. In case of overdose, the usual measures of gastric emptying and general support should be applied. The dose of diclofenac should always be individualized and used at the lowest effective dose to minimize the possible adverse effects. In case of acute overdose, forced diuresis can theoretically be beneficial since the drug is excreted in the urine.

Interaction

Diclofenac:

• increases the effect of oral anticoagulants and heparin.
• increases the hematological toxicity of methotrexate.
• increases the hypoglycemic effect of sulfonylureas.
• increases the plasma concentration of digoxin and lithium.
• increases the nephrotoxicity of cyclosporine.

Pridinol:

• enhancement of anticholinergic effects when taken with: amantadine, quinidine, tricyclic antidepressants, neuroleptics.