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Trexen Duo (Ketoconazole, Clindamycin)

Active Ingredient: Ketoconazole, Clindamycin
Dosage: 100 mg / 400 mg
Route of Administration: Intravaginal
Dosage Form: Suppositories
Quantity per package: 7

Trexen Duo is indicated for the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.

Indications

The drug is indicated in the treatment of bacterial vaginosis caused by Bacteroides spp, Gardnerella vaginalis, Mobiluncus spp, Mycoplasma hominis, as well as other anaerobic germs. Due to its antifungal action, it is indicated in the treatment of vaginal candidiasis and mixed vaginitis.

Dosage and administration

The dose of Trexen Duo is administered vaginally, once a day, preferably at night at bedtime, for 7 consecutive days in pregnant patients and 5 days in non-pregnant patients unless another scheme is advised by the attending physician.

Contraindications

History of hypersensitivity to clindamycin, lincomycin, ketoconazole, any azolic antifungal and the components of the formula.

Side effects

The administration of Trexen Duo intravaginally has caused some adverse reactions in some cases, although its responsibility has not been fully proven. Patients reported symptomatic cervicitis / vaginitis, candidiasis, vaginal trichomoniasis and vulvar irritation. A few cases of local irritation, pruritus and burning sensation have been reported, especially at the beginning of treatment. Due to the minimal absorption of clindamycin and ketoconazole administered vaginally, no systemic adverse reactions have been observed. It can also cause allergic reactions.

Overdose

Cases of overdose with this product have not been reported.

Interaction

Clindamycin shows cross-resistance with lincomycin and antagonistic effect in vitro with erythromycin.

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